Duyos began his career in the fashion world by collaborating with designers such as Manuel Piña and Antonio Pernas, a task he combined with the creation of his first collections together with Cecilia Paniagua for the Duyos & Panigua signature label. In 1999, the designer started his solo career under the Duyos brand and celebrated his first fashion show in Madrid.
Throughout his career he has collaborated with various brands such as Absolut, Levi's, Adidas or Coca-Cola, and from 2002 to 2005, he worked as creative director for fashion brand Don Algodón. In 2009 he presents his collection at New York Fashion Week, within the collective project "4Eyes".[:]