Ana Locking began her career with the Locking Shocking brand of which she was creative director for 10 years. After the dissolution of the brand, she founded her own signature label in 2008, the year in which she made her debut at Madrid Fashion Week.
In September 2009 she presented her work at the New York Public Library within the collective project "4Eyes" during New York Fashion Week. Ana Locking maintains strong ties with other artistic disciplines due to her training in Fine Arts, collaborating with various cultural institutions through exhibits, conferences and courses. The designer emphasizes her commitment to training future fashion professionals, forming part of the teaching staff of the Centro Superior de Diseño de Moda de Madrid since 2011.[:]